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Issue 2, 2013
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Systematic analysis of histone modification readout

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Abstract

To faithfully execute diverse biological programs all cells need to access and distribute their genomes in a highly organized way. In the nucleus of eukaryotic cells DNA is packed with histone proteins into chromatin. The originating nucleo–protein complex is the regulatory platform for all genetic processes. Of these, posttranslational modifications of the histone proteins play a key role as they are thought to direct different chromatin states. Most histone modifications appear to not have a direct effect onto chromatin structure, but work via recruitment of specific binding proteins. A large number of such individual factors interacting with diverse histone marks have been identified and characterized. Also, global approaches have been established that aim to define the interactome of histone modifications or patterns thereof. We summarize the experimental approaches that are used to determine histone modification readout and discuss complexities that are emerging within this regulatory system.

Graphical abstract: Systematic analysis of histone modification readout

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Publication details

The article was received on 10 Aug 2012, accepted on 15 Nov 2012 and first published on 04 Dec 2012


Article type: Review Article
DOI: 10.1039/C2MB25328C
Citation: Mol. BioSyst., 2013,9, 182-194
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    Systematic analysis of histone modification readout

    M. Nikolov and W. Fischle, Mol. BioSyst., 2013, 9, 182
    DOI: 10.1039/C2MB25328C

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