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Issue 17, 2013
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Micro-scale blood plasma separation: from acoustophoresis to egg-beaters

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Abstract

Plasma is a rich mine of various biomarkers including proteins, metabolites and circulating nucleic acids. The diagnostic and therapeutic potential of these analytes has been quite recently uncovered, and the number of plasma biomarkers will still be growing in the coming years. A significant part of the blood plasma preparation is still handled manually, off-chip, via centrifugation or filtration. These batch methods have variable waiting times, and are often performed under non-reproducible conditions that may impair the collection of analytes of interest, with variable degradation. The development of miniaturised modules capable of automated and reproducible blood plasma separation would aid in the translation of lab-on-a-chip devices to the clinical market. Here we propose a systematic review of major plasma analytes and target applications, alongside existing solutions for micro-scale blood plasma extraction, focusing on the approaches that have been biologically validated for specific applications.

Graphical abstract: Micro-scale blood plasma separation: from acoustophoresis to egg-beaters

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Publication details

The article was received on 06 Apr 2013, accepted on 23 May 2013 and first published on 04 Jul 2013


Article type: Critical Review
DOI: 10.1039/C3LC50432H
Citation: Lab Chip, 2013,13, 3323-3346
  • Open access: Creative Commons BY license
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    Micro-scale blood plasma separation: from acoustophoresis to egg-beaters

    M. Kersaudy-Kerhoas and E. Sollier, Lab Chip, 2013, 13, 3323
    DOI: 10.1039/C3LC50432H

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