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Issue 15, 2013
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Functionalization of optical nanotip arrays with an electrochemical microcantilever for multiplexed DNA detection

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Abstract

Optical nanotip arrays fabricated on etched fiber bundles were functionalized with DNA spots. Such unconventional substrates (3D and non-planar) are difficult to pattern with standard microfabrication techniques but, using an electrochemical cantilever, up to 400 spots were electrodeposited on the nanostructured optical surface in 5 min. This approach allows each spot to be addressed individually and multiplexed fluorescence detection is demonstrated. Finally, remote fluorescence detection was performed by imaging through the optical fiber bundle itself after hybridisation with the complementary sequence.

Graphical abstract: Functionalization of optical nanotip arrays with an electrochemical microcantilever for multiplexed DNA detection

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Publication details

The article was received on 13 Mar 2013, accepted on 12 Apr 2013 and first published on 12 Apr 2013


Article type: Paper
DOI: 10.1039/C3LC50335F
Citation: Lab Chip, 2013,13, 2956-2962
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    Functionalization of optical nanotip arrays with an electrochemical microcantilever for multiplexed DNA detection

    E. Descamps, N. Duroure, F. Deiss, T. Leichlé, C. Adam, P. Mailley, A. Aït-Ikhlef, T. Livache, L. Nicu and N. Sojic, Lab Chip, 2013, 13, 2956
    DOI: 10.1039/C3LC50335F

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