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Issue 10, 2013
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Microfluidic serial digital to analog pressure converter for arbitrary pressure generation and contamination-free flow control

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Abstract

Multilayer microfluidics based on PDMS (polydimethylsiloxane) soft lithography have offered parallelism and integration for biological and chemical sciences, where reduction in reaction volume and consistency of controlled variables across experiments translate into reduced cost, increased quantity and quality of data. One issue with push up or push down microfluidic control concept is the inability to provide multiple control pressures without adding more complex and expensive external pressure controls. We present here a microfluidic serial DAC (Digital to Analog Converter) that can be integrated with any PDMS device to expand the device's functionality by effectively adding an on-chip pressure regulator. The microfluidic serial DAC can be used with any incompressible fluids and operates in a similar fashion compared to an electronic serial DAC. It can be easily incorporated into any existing multilayer microfluidic devices, and the output pressure that the device generates could be held for extensive times. We explore in this paper various factors that affect resolution, speed, and linearity of the DAC output. As an application, we demonstrate microfluidic DAC's ability for on-chip manipulation of flow resistance when integrated with a simple flow network. In addition, we illustrate an added advantage of using the microfluidic serial DAC in preventing back flow and possible contamination.

Graphical abstract: Microfluidic serial digital to analog pressure converter for arbitrary pressure generation and contamination-free flow control

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Publication details

The article was received on 19 Dec 2012, accepted on 04 Mar 2013 and first published on 04 Mar 2013


Article type: Paper
DOI: 10.1039/C3LC41394B
Citation: Lab Chip, 2013,13, 1911-1918
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    Microfluidic serial digital to analog pressure converter for arbitrary pressure generation and contamination-free flow control

    F. Yu, M. A. Horowitz and S. R. Quake, Lab Chip, 2013, 13, 1911
    DOI: 10.1039/C3LC41394B

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