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Issue 7, 2013
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SU-8 based microprobes for simultaneous neural depth recording and drug delivery in the brain

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Abstract

While novel influential concepts in neuroscience bring the focus to local activities generated within a few tens of cubic micrometers in the brain, we are still devoid of appropriate tools to record and manipulate pharmacologically neuronal activity at this fine scale. Here we designed, fabricated and encapsulated microprobes for simultaneous depth recording and drug delivery using exclusively the polymer SU-8 as structural material. A tetrode- and linear-like electrode patterning was combined for the first time with single and double fluidic microchannels for independent drug delivery. The device was tested experimentally using the in vivo anesthetized rat preparation. Both probe types successfully recorded detailed spatiotemporal features of local field potentials and single-cell activity at a resolution never attained before with integrated fluidic probes. Drug delivery was achieved with high spatial and temporal precision in a range from tens of nanoliters to a few microliters, as confirmed histologically. These technological advancements will foster a wide range of neural applications aimed at simultaneous monitoring of brain activity and delivery at a very precise micrometer scale.

Graphical abstract: SU-8 based microprobes for simultaneous neural depth recording and drug delivery in the brain

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Publication details

The article was received on 12 Dec 2012, accepted on 18 Jan 2013 and first published on 21 Jan 2013


Article type: Paper
DOI: 10.1039/C3LC41364K
Citation: Lab Chip, 2013,13, 1422-1430
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    SU-8 based microprobes for simultaneous neural depth recording and drug delivery in the brain

    A. Altuna, E. Bellistri, E. Cid, P. Aivar, B. Gal, J. Berganzo, G. Gabriel, A. Guimerà, R. Villa, L. J. Fernández and L. Menendez de la Prida, Lab Chip, 2013, 13, 1422
    DOI: 10.1039/C3LC41364K

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