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Issue 8, 2013
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Engineering a 3D vascular network in hydrogel for mimicking a nephron

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Abstract

Engineering functional vascular networks in vitro is critical for tissue engineering and a variety of applications. There is still a general lack of straightforward approaches for recapitulating specific structures and functions of vasculature. This report describes a microfluidic method that utilizes fibrillogenesis of collagen and a liquid mold to engineer three-dimensional vascular networks in hydrogel. The well-controlled vascular network demonstrates both mechanical stability for perfusing solutions and biocompatibility for cell adhesion and coverage. This technique enables the mimicry of passive diffusion in a nephron one of the main routes transferring soluble organic molecules. This approach could be used for in vitro modelling of mass transfer-involved physiology in vasculature-rich tissues and organs for regeneration and drug screening.

Graphical abstract: Engineering a 3D vascular network in hydrogel for mimicking a nephron

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Publication details

The article was received on 06 Dec 2012, accepted on 25 Jan 2013 and first published on 28 Jan 2013


Article type: Paper
DOI: 10.1039/C3LC41342J
Citation: Lab Chip, 2013,13, 1612-1618
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    Engineering a 3D vascular network in hydrogel for mimicking a nephron

    X. Mu, W. Zheng, L. Xiao, W. Zhang and X. Jiang, Lab Chip, 2013, 13, 1612
    DOI: 10.1039/C3LC41342J

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