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Issue 13, 2013
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Recent advances in microfluidic techniques for single-cell biophysical characterization

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Abstract

Biophysical (mechanical and electrical) properties of living cells have been proven to play important roles in the regulation of various biological activities at the molecular and cellular level, and can serve as promising label-free markers of cells' physiological states. In the past two decades, a number of research tools have been developed for understanding the association between the biophysical property changes of biological cells and human diseases; however, technical challenges of realizing high-throughput, robust and easy-to-perform measurements on single-cell biophysical properties have yet to be solved. In this paper, we review emerging tools enabled by microfluidic technologies for single-cell biophysical characterization. Different techniques are compared. The technical details, advantages, and limitations of various microfluidic devices are discussed.

Graphical abstract: Recent advances in microfluidic techniques for single-cell biophysical characterization

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Publication details

The article was received on 18 Mar 2013, accepted on 16 Apr 2013 and first published on 17 Apr 2013


Article type: Critical Review
DOI: 10.1039/C3LC50355K
Citation: Lab Chip, 2013,13, 2464-2483
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    Recent advances in microfluidic techniques for single-cell biophysical characterization

    Y. Zheng, J. Nguyen, Y. Wei and Y. Sun, Lab Chip, 2013, 13, 2464
    DOI: 10.1039/C3LC50355K

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