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Issue 12, 2013
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Probing subcellular organic hydroperoxide formation via a genetically encoded ratiometric and reversible fluorescent indicator

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Abstract

A ratiometric and reversible organic hydroperoxide (OHP) sensor, rOHSer, was developed with high sensitivity and selectivity for subcellular OHP visualization. Through targeting rOHSer to the nucleus, we demonstrated that high levels of D-glucose cause elevated OHP production in this compartment. Further utilization of rOHSer probe may allow more elucidation of unique roles of OHPs in diverse biological processes.

Graphical abstract: Probing subcellular organic hydroperoxide formation via a genetically encoded ratiometric and reversible fluorescent indicator

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Publication details

The article was received on 08 Oct 2013, accepted on 19 Oct 2013 and first published on 22 Oct 2013


Article type: Paper
DOI: 10.1039/C3IB40209F
Citation: Integr. Biol., 2013,5, 1485-1489
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    Probing subcellular organic hydroperoxide formation via a genetically encoded ratiometric and reversible fluorescent indicator

    B. S. Zhao, G. Zhang, S. Zeng, C. He and P. R. Chen, Integr. Biol., 2013, 5, 1485
    DOI: 10.1039/C3IB40209F

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