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Issue 3, 2013
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Non-dimensional analysis of retinal microaneurysms: critical threshold for treatment

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Abstract

Fluid dynamics play a fundamental role in the development of diabetic retinopathy, one of the leading causes of blindness in the Western world, affecting over 4 million people in the US alone. The disease is defined by microaneurysms, local expansions of capillaries that disturb the hemodynamic forces experienced by the endothelium leading to dysfunction, leakage and edema. Here we present a method to identify microaneurysms with a high risk of leakage based on a critical ratio of microaneurysm to vessel diameter. We derive this non-dimensional parameter from an analytical solution and generalize it using experimentally validated numerical methods. We show that this non-dimensional parameter defines the shear force experienced by endothelial cells, below which endothelial dysfunction is evident in vivo. Our results demonstrate the involvement of vWF in diabetic retinopathy, and explain a perceived disconnect between microaneurysm size and leakage. This method will allow experts to treat microaneurysms poising a high-risk of leakage, prior to edema, minimizing damage and saving vision.

Graphical abstract: Non-dimensional analysis of retinal microaneurysms: critical threshold for treatment

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Publication details

The article was received on 24 Oct 2012, accepted on 04 Jan 2013 and first published on 14 Jan 2013


Article type: Paper
DOI: 10.1039/C3IB20259C
Citation: Integr. Biol., 2013,5, 474-480
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    Non-dimensional analysis of retinal microaneurysms: critical threshold for treatment

    E. Ezra, E. Keinan, Y. Mandel, M. E. Boulton and Y. Nahmias, Integr. Biol., 2013, 5, 474
    DOI: 10.1039/C3IB20259C

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