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Issue 3, 2013
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Mechanobiology: a new frontier for human pluripotent stem cells

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Abstract

Research on human pluripotent stem cells (hPSCs) has expanded rapidly over the last two decades, owing to the promises of hPSCs for applications in regenerative medicine, disease modeling, and developmental biology studies. While most studies of hPSCs have so far focused on identifying extrinsic soluble factors, intracellular signaling pathways, and transcriptional networks that are involved in regulating hPSC self-renewal and differentiation, a few promising studies have emerged in recent years to reveal some unique mechano-sensitive and -responsive properties of hPSCs and the effect of the physical aspects of the local cellular microenvironment on regulating hPSC behaviors. This Frontier Review is to highlight these recent studies of mechanobiology in hPSCs and to discuss the impact of advancing our understanding of mechanoregulation of hPSC behaviors on improving survival, self-renewal and differentiation of hPSCs using well-controlled synthetic micro/nanoscale cell culture tools.

Graphical abstract: Mechanobiology: a new frontier for human pluripotent stem cells

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Publication details

The article was received on 20 Oct 2012, accepted on 16 Dec 2012 and first published on 18 Dec 2012


Article type: Frontier
DOI: 10.1039/C2IB20256E
Citation: Integr. Biol., 2013,5, 450-457
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    Mechanobiology: a new frontier for human pluripotent stem cells

    Y. Sun and J. Fu, Integr. Biol., 2013, 5, 450
    DOI: 10.1039/C2IB20256E

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