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Issue 1, 2013
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Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging

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Abstract

We have recently developed compact and water-soluble zwitterionic dopamine sulfonate (ZDS) ligand coated superparamagnetic iron oxide nanoparticles (SPIONs) for use in various biomedical applications. The defining characteristics of ZDS-coated SPIONs are small hydrodynamic diameters, low non-specific interactions with fetal bovine serum, the opportunity for specific labeling, and stability with respect to time, pH, and salinity. We report here on the magnetic characterization of ZDS-coated SPIONs and their in vitro and in vivo performance relative to non-specific interactions with HeLa cells and in mice, respectively. ZDS-coated SPIONs retained the superparamagnetism and saturation magnetization (Ms) of as-synthesized hydrophobic SPIONs, with Ms = 74 emu gāˆ’1 [Fe]. Moreover, ZDS-coated SPIONs showed only small non-specific uptake into HeLa cancer cells in vitro and low non-specific binding to serum proteins in vivo in mice.

Graphical abstract: Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging

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Publication details

The article was received on 07 Jun 2012, accepted on 12 Sep 2012 and first published on 05 Oct 2012


Article type: Paper
DOI: 10.1039/C2IB20142A
Citation: Integr. Biol., 2013,5, 108-114
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    Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging

    H. Wei, O. T. Bruns, O. Chen and M. G. Bawendi, Integr. Biol., 2013, 5, 108
    DOI: 10.1039/C2IB20142A

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