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Issue 7, 2013
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Unusual reactions mediated by FMN-dependent ene- and nitro-reductases

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Abstract

Due to the chemical versatility of the flavin cofactor, FMN-dependent ene-reductases and nitro-reductases can catalyze or mediate a diverse spectrum of chemical reactions. Among them, two-electron transfer reactions dominate, which may proceed via sequential hydride transfer at the same or at alternate reactive sites. In addition, highly reactive intermediates are often formed, which undergo subsequent spontaneous (non-enzymatic) reactions leading to further enzymatic transformations in a cascade. Besides the well-known reductive processes involving alkenes and nitro groups at the expense of a reduced flavin cofactor, redox-neutral processes including disproportionation and C[double bond, length as m-dash]C-bond isomerization reactions are catalyzed by OYE homologues. Unusual flavin-dependent biotransformations are reviewed with a special focus on the OYE family of flavoproteins (ene-reductases) and oxygen-insensitive FMN-dependent nitro-reductases.

Graphical abstract: Unusual reactions mediated by FMN-dependent ene- and nitro-reductases

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Publication details

The article was received on 27 Mar 2013, accepted on 24 Apr 2013 and first published on 24 Apr 2013


Article type: Critical Review
DOI: 10.1039/C3GC40588E
Citation: Green Chem., 2013,15, 1764-1772
  • Open access: Creative Commons BY-NC license
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    Unusual reactions mediated by FMN-dependent ene- and nitro-reductases

    K. Durchschein, M. Hall and K. Faber, Green Chem., 2013, 15, 1764
    DOI: 10.1039/C3GC40588E

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