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Issue 5, 2013
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Development of a solvent selection guide for aldehyde-based direct reductive amination processes

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Abstract

A range of alternative, more environmentally conservative solvents have been evaluated for use within the direct reductive amination reactions of aldehydes using borane-based reductants. The data generated has been used to develop a guide to facilitate replacement of less desirable chlorinated solvents, such as DCE, from these widely used synthetic processes.

Graphical abstract: Development of a solvent selection guide for aldehyde-based direct reductive amination processes

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Publication details

The article was received on 19 Feb 2013, accepted on 09 Apr 2013 and first published on 09 Apr 2013


Article type: Communication
DOI: 10.1039/C3GC40359A
Citation: Green Chem., 2013,15, 1159-1165
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    Development of a solvent selection guide for aldehyde-based direct reductive amination processes

    F. I. McGonagle, D. S. MacMillan, J. Murray, H. F. Sneddon, C. Jamieson and A. J. B. Watson, Green Chem., 2013, 15, 1159
    DOI: 10.1039/C3GC40359A

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