Jump to main content
Jump to site search

Issue 2, 2013
Previous Article Next Article

Microwave-assisted, sequential four-component synthesis of polysubstituted 5,6-dihydroquinazolinones from acyclic precursors and a mild, halogenation-initiated method for their aromatization under focused microwave irradiation

Author affiliations

Abstract

A one-pot, microwave-assisted protocol has been developed for the synthesis of 5,6-dihydroquinazolinones that incorporate structural fragments from chalcones, acetylacetoacetate, ammonium formate and formamide. This process generates two rings, two carbon–carbon and three carbon–nitrogen bonds and does not require the use of chromatographic purification. The dihydroquinazolinones were efficiently aromatized without the need for metal-based oxidants by a microwave-assisted halogenation–elimination sequence in the presence of N-bromosuccinimide, again in the absence of chromatographic purification.

Graphical abstract: Microwave-assisted, sequential four-component synthesis of polysubstituted 5,6-dihydroquinazolinones from acyclic precursors and a mild, halogenation-initiated method for their aromatization under focused microwave irradiation

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Aug 2012, accepted on 27 Nov 2012 and first published on 27 Nov 2012


Article type: Paper
DOI: 10.1039/C2GC36221J
Citation: Green Chem., 2013,15, 511-517
  •   Request permissions

    Microwave-assisted, sequential four-component synthesis of polysubstituted 5,6-dihydroquinazolinones from acyclic precursors and a mild, halogenation-initiated method for their aromatization under focused microwave irradiation

    D. Rocchi, J. F. González and J. C. Menéndez, Green Chem., 2013, 15, 511
    DOI: 10.1039/C2GC36221J

Search articles by author

Spotlight

Advertisements