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Issue 12, 2013
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GAP chemistry for pyrrolyl coumarin derivatives: a highly efficient one-pot synthesis under catalyst-free conditions

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Abstract

A concise and efficient one-pot synthesis of pyrrolyl coumarin derivatives via a four-component reaction of 4-hydroxycoumarin, arylglyoxal monohydrate, dialkyl but-2-ynedioate and amines under catalyst-free conditions in an environmentally friendly medium (ethanol) is described. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional chromatography and recrystallization purification methods.

Graphical abstract: GAP chemistry for pyrrolyl coumarin derivatives: a highly efficient one-pot synthesis under catalyst-free conditions

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Publication details

The article was received on 31 Aug 2013, accepted on 24 Sep 2013 and first published on 25 Sep 2013


Article type: Communication
DOI: 10.1039/C3GC41799A
Citation: Green Chem., 2013,15, 3307-3311
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    GAP chemistry for pyrrolyl coumarin derivatives: a highly efficient one-pot synthesis under catalyst-free conditions

    H. Wang, X. Liu, X. Feng, Z. Huang and D. Shi, Green Chem., 2013, 15, 3307
    DOI: 10.1039/C3GC41799A

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