Issue 11, 2013
From the journal:

Green Chemistry

Development of a robust reagent for the two-carbon homologation of aldehydes to (E)-α,β-unsaturated aldehydes in water†

James McNulty,*a   Carlos Zepeda-Velázqueza  and  David McLeoda  

* Corresponding authors

a Department of Chemistry & Chemical Biology, McMaster University, 1280 main Street West, Hamilton, Ontario, Canada
E-mail: jmcnult@mcmaster.ca
Tel: +1-905 525 9140 ext. 27393

Abstract

Synthesis of a new pinacolacetal-phosphonium salt and its reaction with aldehydes to give homologated acetals and two-carbon homologated unsaturated aldehydes is presented. The chemistry takes place in water under mild conditions and the sequence can be performed in one-flask operation.

Graphical abstract: Development of a robust reagent for the two-carbon homologation of aldehydes to (E)-α,β-unsaturated aldehydes in water

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Article information

DOI
https://doi.org/10.1039/C3GC41383G
Article type
Communication
Submitted
11 Jul 2013
Accepted
09 Sep 2013
First published
09 Sep 2013

Green Chem., 2013,15, 3146-3149

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Development of a robust reagent for the two-carbon homologation of aldehydes to (E)-α,β-unsaturated aldehydes in water

J. McNulty, C. Zepeda-Velázquez and D. McLeod, Green Chem., 2013, 15, 3146 DOI: 10.1039/C3GC41383G

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