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Issue 1, 2013
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Synthesis of antimalarial trioxanes via continuous photo-oxidation with 1O2 in supercritical CO2

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Abstract

The oxidation of an allylic alcohol to its hydroperoxides represents a key step in the synthesis of a series of spirobicyclic, antimalarial trioxanes. Herein, we investigate the continuous photo-oxidation of an allylic alcohol with 1O2 in scCO2, as a ‘green’ alternative to conventional methods, and examine the remaining two steps in the synthesis of antimalarial trioxanes from readily available starting materials.

Graphical abstract: Synthesis of antimalarial trioxanes via continuous photo-oxidation with 1O2 in supercritical CO2

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Publication details

The article was received on 29 Oct 2012, accepted on 15 Nov 2012 and first published on 15 Nov 2012


Article type: Paper
DOI: 10.1039/C2GC36711D
Citation: Green Chem., 2013,15, 177-180
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    Synthesis of antimalarial trioxanes via continuous photo-oxidation with 1O2 in supercritical CO2

    J. F. B. Hall, R. A. Bourne, X. Han, J. H. Earley, M. Poliakoff and M. W. George, Green Chem., 2013, 15, 177
    DOI: 10.1039/C2GC36711D

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