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Issue 6, 2013
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Flavonoids as dietary regulators of nuclear receptor activity

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Abstract

Metabolic diseases such as obesity, type II diabetes, and dyslipidemia are a rising cause of mortality worldwide. The progression of many metabolic diseases is fundamentally regulated on the transcriptional level by a family of ligand-activated transcription factors, called nuclear receptors, which detect and respond to metabolic changes. Their role in maintaining metabolic homeostasis makes nuclear receptors an important pharmaceutical and dietary target. This review will present the growing evidence that flavonoids, natural secondary plant metabolites, are important regulators of nuclear receptor activity. Structural similarities between flavonoids and cholesterol derivatives combined with the promiscuous nature of most nuclear receptors provide a wealth of possibilities for pharmaceutical and dietary modulation of metabolism. While the challenges of bringing flavonoid-derived therapeutics to the market are significant, we consider this rapidly growing field to be an essential aspect of the functional food initiative and an important mine for pharmaceutical compounds.

Graphical abstract: Flavonoids as dietary regulators of nuclear receptor activity

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Publication details

The article was received on 10 Feb 2013, accepted on 22 Mar 2013 and first published on 19 Apr 2013


Article type: Review Article
DOI: 10.1039/C3FO60063G
Citation: Food Funct., 2013,4, 831-844
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    Flavonoids as dietary regulators of nuclear receptor activity

    Y. Avior, D. Bomze, O. Ramon and Y. Nahmias, Food Funct., 2013, 4, 831
    DOI: 10.1039/C3FO60063G

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