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Issue 4, 2013
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Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-γ and SREBP-1c in diet-induced obese mice

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Abstract

The growing incidence of obesity is a worldwide public health problem leading to a risk factor for non-alcoholic fatty liver disease, which extends from steatosis to steatohepatitis and cirrhosis. We investigated whether the aqueous extract of Hibiscus sabdariffa L. (Hs) reduces body weight gain and protects the liver by improving lipid metabolism in high fat diet-induced obese C57BL/6NHsd mice. We found that oral administration of the Hs extract reduced fat tissue accumulation, diminished body weight gain and normalized the glycemic index as well as reduced dyslipidemia compared to the obese mice group that did not receive Hs treatment. In addition, Hs treatment attenuated liver steatosis, down-regulated SREBP-1c and PPAR-γ, blocked the increase of IL-1, TNF-α mRNA and lipoperoxidation and increased catalase mRNA. Our results suggest that the anti-obesity, anti-lipidemic and hepatoprotective effects of the Hs extract are related to the regulation of PPAR-γ and SREBP-1c in the liver.

Graphical abstract: Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-γ and SREBP-1c in diet-induced obese mice

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Publication details

The article was received on 02 Oct 2012, accepted on 22 Jan 2013 and first published on 07 Feb 2013


Article type: Paper
DOI: 10.1039/C3FO30270A
Citation: Food Funct., 2013,4, 618-626
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    Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-γ and SREBP-1c in diet-induced obese mice

    E. V. Villalpando-Arteaga, E. Mendieta-Condado, H. Esquivel-Solís, A. A. Canales-Aguirre, F. J. Gálvez-Gastélum, J. C. Mateos-Díaz, J. A. Rodríguez-González and A. L. Márquez-Aguirre, Food Funct., 2013, 4, 618
    DOI: 10.1039/C3FO30270A

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