Elastic properties of polyunsaturated phosphatidylethanolamines influence rhodopsin function

Walter E. Teague; Olivier Soubias; Horia Petrache; Nola Fuller; Kirk G. Hines; R. Peter Rand; Klaus Gawrisch

doi:10.1039/C2FD20095C

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Faraday Discussions

Issue 0, 2013

Discussion summary and research papers, in physical chemistry, chemical physics and biophysical chemistry.

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Paper

Elastic properties of polyunsaturated phosphatidylethanolamines influence rhodopsin function

Walter E. Teague,^a Olivier Soubias,^a Horia Petrache,^b Nola Fuller,^c Kirk G. Hines,^a R. Peter Rand^c and Klaus Gawrisch*^a

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Corresponding authors

Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, USA
E-mail: gawrisch@helix.nih.gov ;
Fax: +1-301-594-0035 ;
Tel: +1-301-594-3750

Department of Physics, Indiana University–Perdue University, Indianapolis, USA
E-mail: hpetrach@iupui.edu ;
Fax: +1-317-274-2392 ;
Tel: +1-317-278-6521

Department of Biological Science, Brock University, St. Catharines, Canada
E-mail: rrand@brocku.ca ;
Tel: +1-905-688-5550 ext.3388

Faraday Discuss., 2013,161, 383-395

DOI: 10.1039/C2FD20095C
Received 02 May 2012, Accepted 28 Jun 2012
First published online 29 Jun 2012

This article is part of themed collection: Lipids & Membrane Biophysics

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Abstract
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Membranes with a high content of polyunsaturated phosphatidylethanolamines (PE) facilitate formation of metarhodopsin-II (M_II), the photointermediate of bovine rhodopsin that activates the G protein transducin. We determined whether M_II-formation is quantitatively linked to the elastic properties of PEs. Curvature elasticity of monolayers of the polyunsaturated lipids 18:0–22:6_n−3PE, 18:0–22:5_n−6PE and the model lipid 18:1_n−9–18:1_n−9PE were investigated in the inverse hexagonal phase. All three lipids form lipid monolayers with rather low spontaneous radii of curvature of 26–28 Å. In membranes, all three PEs generate high negative curvature elastic stress that shifts the equilibrium of M_I/M_II photointermediates of rhodopsin towards M_II formation.