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Issue 27, 2013
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Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

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Abstract

Binding of Leu-enkephalin and [RhIII5-Cp*)(η6-Tyr1)]Leu-enkephalin to the recently published crystal structures of the μ- and δ-opioid receptor is studied. Docking of free Leu-enkephalin reveals two preferred conformations, one of which suggests an alternative binding site for the tyrosine residue. Furthermore, the three-dimensional solution structure of [RhIII5-Cp*)(η6-Tyr1)]Leu-enkephalin was solved by using 2D NMR spectroscopic techniques.

Graphical abstract: Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

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Publication details

The article was received on 23 Dec 2012, accepted on 08 Mar 2013 and first published on 22 Mar 2013


Article type: Communication
DOI: 10.1039/C3DT50635E
Citation: Dalton Trans., 2013,42, 9799-9802
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    Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

    F. Wieberneit, A. Korste, H. B. Albada, N. Metzler-Nolte and R. Stoll, Dalton Trans., 2013, 42, 9799
    DOI: 10.1039/C3DT50635E

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