A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI

Bo Song; Yunkou Wu; Mengxiao Yu; Piyu Zhao; Chen Zhou; Garry E. Kiefer; A. Dean Sherry

doi:10.1039/C3DT50194A

A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI

Bo Song,^a^c Yunkou Wu,^b Mengxiao Yu,^a Piyu Zhao,^a Chen Zhou,^a Garry E. Kiefer^a^d and A. Dean Sherry*^a^b

* Corresponding authors

^a Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, USA
E-mail: sherry@utdallas.edu
Fax: +1 972-883-2907
Tel: +1 972-883-2907

^b Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, USA

^c State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology, Dalian 116024, China

^d Macrocyclics, Inc., 1309 Record Crossing, Dallas, USA

Abstract

A europium(III) DOTA-tetraamide complex was designed as a MRI sensor of singlet oxygen (¹O₂). The water soluble, thermodynamically stable complex reacts rapidly with ¹O₂ to form an endoperoxide derivative that results in an ∼3 ppm shift in the position of the Eu(III)-bound water chemical exchange saturation transfer (CEST) peak. The potential of using this probe to detect accumulation of the endoperoxide derivative in biological media by ratiometric CEST imaging was demonstrated.

Supplementary files

Publication details

The article was received on 18 Jan 2013, accepted on 04 Apr 2013 and first published on 04 Apr 2013

Article type: Paper

DOI: 10.1039/C3DT50194A

Citation: Dalton Trans., 2013,42, 8066-8069

Request permissions
A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI

B. Song, Y. Wu, M. Yu, P. Zhao, C. Zhou, G. E. Kiefer and A. D. Sherry, Dalton Trans., 2013, 42, 8066
DOI: 10.1039/C3DT50194A
If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.

Authors contributing to RSC publications (journal articles, books or book chapters) do not need to formally request permission to reproduce material contained in this article provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:
For reproduction of material from NJC:
Reproduced from Ref. XX with permission from the Centre National de la Recherche Scientifique (CNRS) and The Royal Society of Chemistry.

For reproduction of material from PCCP:
Reproduced from Ref. XX with permission from the PCCP Owner Societies.

For reproduction of material from PPS:
Reproduced from Ref. XX with permission from the European Society for Photobiology, the European Photochemistry Association, and The Royal Society of Chemistry.

For reproduction of material from all other RSC journals and books:
Reproduced from Ref. XX with permission from The Royal Society of Chemistry.
If the material has been adapted instead of reproduced from the original RSC publication "Reproduced from" can be substituted with "Adapted from".

In all cases the Ref. XX is the XXth reference in the list of references.

If you are the author of this article you do not need to formally request permission to reproduce figures, diagrams etc. contained in this article in third party publications or in a thesis or dissertation provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:
For reproduction of material from NJC:
[Original citation] - Reproduced by permission of The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC

For reproduction of material from PCCP:
[Original citation] - Reproduced by permission of the PCCP Owner Societies

For reproduction of material from PPS:
[Original citation] - Reproduced by permission of The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC

For reproduction of material from all other RSC journals:
[Original citation] - Reproduced by permission of The Royal Society of Chemistry
If you are the author of this article you still need to obtain permission to reproduce the whole article in a third party publication with the exception of reproduction of the whole article in a thesis or dissertation.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Dalton Transactions

A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI

Abstract

Supplementary files

Publication details

A europium(III)-based PARACEST agent for sensing singlet oxygen by MRI

Search articles by author

Spotlight

Advertisements