Screening organometallic binuclear thiosemicarbazone ruthenium complexes as potential anti-tumour agents: cytotoxic activity and human serum albumin binding mechanism†
Abstract
Four complexes combining the {Ru(p-cym)} moiety (p-cym =
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* Corresponding authors
a Cátedra de Química Inorgánica, Facultad de Química, Universidad de la República, 11800 Montevideo, Uruguay
b Centro de Química e Bioquímica, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade de Lisboa, 1749-016 Lisbon, Portugal
c Unidade de Ciências Químicas e Radiofarmacêuticas, Instituto Superior Técnico, Pólo de Loures – Campus Tecnológico e Nuclear, Estrada Nacional 10, 2686-953 Sacavém, Portugal
d
Centro de Ciências Moleculares e Materiais, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, 1749-016 Lisbon, Portugal
E-mail:
isabel.tomaz@fc.ul.pt
e Centro de Química Estrutural, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal
f Departament de Química Inorgànica, Universitat de Barcelona, Martí i Franquès 1-11, 08028 Barcelona, Spain
g Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, 08193-Bellaterra, Barcelona, Spain
Four complexes combining the {Ru(p-cym)} moiety (p-cym =
B. Demoro, R. F. M. de Almeida, F. Marques, C. P. Matos, L. Otero, J. Costa Pessoa, I. Santos, A. Rodríguez, V. Moreno, J. Lorenzo, D. Gambino and A. I. Tomaz, Dalton Trans., 2013, 42, 7131 DOI: 10.1039/C3DT00028A
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