Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Tuesday 6th February 2018 from 11.00am to 11.15am (GMT).

During this time our website performance may be temporarily affected. If you have any questions please use the feedback button available under our menu button. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 10, 2014
Previous Article Next Article

Development of ruthenium(II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

Author affiliations

Abstract

A series of ruthenium(II) bis(2,2′-bipyridyl) complexes containing N-phenyl-substituted diazafluorenes (Ru-C1, Ru-C6, Ru-C7 and Ru-F) was synthesized and their potential antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) was investigated. The Ru-C7 complex showed significant improvement in both minimum inhibitory concentration (MIC, 6.25 μg mL−1) and minimum bactericidal concentration (MBC, 25 μg mL−1) towards MRSA when compared with those of methicillin (positive control) (MIC = 25 μg mL−1 and MBC = 100 μg mL−1). The Ru-C7 complex possessed much stronger antibacterial effects than the Ru-C6 complex (MIC, 25 μg mL−1, MBC, >100 μg mL−1). Both Ru-C6 and Ru-C7 complexes were also demonstrated to be biologically safe when tested on normal human skin keratinocytes.

Graphical abstract: Development of ruthenium(ii) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Oct 2013, accepted on 14 Dec 2013 and first published on 16 Dec 2013


Article type: Paper
DOI: 10.1039/C3DT52879K
Citation: Dalton Trans., 2014,43, 3949-3957
  •   Request permissions

    Development of ruthenium(II) complexes as topical antibiotics against methicillin resistant Staphylococcus aureus

    P.-L. Lam, G.-L. Lu, K.-M. Hon, K.-W. Lee, C.-L. Ho, X. Wang, J. C.-O. Tang, K.-H. Lam, R. S.-M. Wong, S. H.-L. Kok, Z.-X. Bian, H. Li, K. K.-H. Lee, R. Gambari, C.-H. Chui and W.-Y. Wong, Dalton Trans., 2014, 43, 3949
    DOI: 10.1039/C3DT52879K

Search articles by author

Spotlight

Advertisements