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Issue 13, 2014
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Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors

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Abstract

Diaryl-substituted ortho-carboranes 1 were synthesized from the corresponding alkynes by decaborane coupling under microwave-irradiated conditions with a combination of N,N-dimethylaniline and chlorobenzene. Among the compounds synthesized, 1a and 1d exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity. Both compounds similarly suppressed hypoxia-induced HIF-1α accumulation in a concentration-dependent manner without affecting HIF-1α mRNA expression.

Graphical abstract: Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors

  • This article is part of the themed collection: Carboranes
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Publication details

The article was received on 09 Oct 2013, accepted on 18 Nov 2013 and first published on 19 Nov 2013


Article type: Communication
DOI: 10.1039/C3DT52828F
Citation: Dalton Trans., 2014,43, 4941-4944
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    Diaryl-substituted ortho-carboranes as a new class of hypoxia inducible factor-1α inhibitors

    H. Nakamura, L. Tasaki, D. Kanoh, S. Sato and H. S. Ban, Dalton Trans., 2014, 43, 4941
    DOI: 10.1039/C3DT52828F

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