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Issue 2, 2014
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A highly fluorescent chemosensor for Zn2+ and the recognition research on distinguishing Zn2+ from Cd2+

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Abstract

A new fluorescent sensor, 2-(2-oxo-2-(quinolin-8-ylamino)ethoxy)-N-(pyridine-2-ylmethyl) benzamide (L), composed of a quinoline group as the fluorogenic unit and a pyridin-2-ylmethanamine as the binding unit for metal ions has been synthesized. The sensor shows excellent selectivity and sensitivity with a fluorescence enhancement to Zn2+ over other cations in acetonitrile aqueous solution. The X-ray crystal structure analysis reveals that sensor L coordinates to Zn2+via a 1 : 1 binding mode but to Cd2+via a 2 : 1 binding mode, which lead to a different spatial arrangement of the fluorogenic unit in these complexes. In addition, density functional theory calculations on L, and the Zn2+/L and Cd2+/L complexes also imply that the different structures of L significantly affect the molecular orbital energy levels and electron transition, which would result in the spectral changes to distinguish Zn2+ from Cd2+. The absorption study results may also suggest the Cd2+ in the complex can be displaced by Zn2+. Furthermore, the fluorescence imaging of Zn2+ in living cells was obtained.

Graphical abstract: A highly fluorescent chemosensor for Zn2+ and the recognition research on distinguishing Zn2+ from Cd2+

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Publication details

The article was received on 08 Aug 2013, accepted on 25 Sep 2013 and first published on 25 Sep 2013


Article type: Paper
DOI: 10.1039/C3DT52165F
Citation: Dalton Trans., 2014,43, 706-713
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    A highly fluorescent chemosensor for Zn2+ and the recognition research on distinguishing Zn2+ from Cd2+

    P. Li, X. Zhou, R. Huang, L. Yang, X. Tang, W. Dou, Q. Zhao and W. Liu, Dalton Trans., 2014, 43, 706
    DOI: 10.1039/C3DT52165F

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