Jump to main content
Jump to site search

Issue 3, 2014
Previous Article Next Article

Carbohydrate-appended photocytotoxic (imidazophenanthroline)-oxovanadium(IV) complexes for cellular targeting and imaging

Author affiliations

Abstract

Oxovanadium(IV) complexes [VO(aip)(L)](ClO4)2 (L = phtpy, 1; stpy, 2) and [VO(pyip)(L)](ClO4)2 (L = phtpy, 3; stpy, 4), where aip is 2-(9-anthryl)-1H-imidazo[4,5-f][1,10]phenanthroline, pyip is [2-(1-pyrenyl)-1H-imidazo[4,5-f][1,10]phenanthroline, phtpy is (4′-phenyl)-2,2′:6′,2′′-terpyridine and stpy is (2,2′:6′,2′′-terpyridin-4′-oxy)ethyl-β-D-glucopyranoside, were prepared, characterized and their DNA binding and photocleavage activity, cellular uptake and photocytotoxicity in visible light were studied. The complexes are avid binders to calf thymus DNA (Kb ∼105 mol−1). They efficiently cleave pUC19 DNA in red light of 705 nm via the formation of HO˙ species. The glucose appended complexes 2 and 4 showed higher photocytotoxicity in HeLa and Hep G2 cells over the normal HEK 293T cells. No such preference was observed for the phtpy complexes 1 and 3. No significant difference in IC50 values was observed for the HEK 293T cells. Cell cycle analysis showed that the glucose appended complexes 2 and 4 are more photocytotoxic in cancer cells than in normal cells. Fluorescence microscopy was done to study the cellular localization of complex 4 having a pendant pyrenyl group.

Graphical abstract: Carbohydrate-appended photocytotoxic (imidazophenanthroline)-oxovanadium(iv) complexes for cellular targeting and imaging

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 01 Aug 2013, accepted on 15 Oct 2013 and first published on 16 Oct 2013


Article type: Paper
DOI: 10.1039/C3DT52087K
Citation: Dalton Trans., 2014,43, 1321-1331
  •   Request permissions

    Carbohydrate-appended photocytotoxic (imidazophenanthroline)-oxovanadium(IV) complexes for cellular targeting and imaging

    B. Banik, K. Somyajit, A. Hussain, G. Nagaraju and A. R. Chakravarty, Dalton Trans., 2014, 43, 1321
    DOI: 10.1039/C3DT52087K

Search articles by author