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Issue 42, 2013
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New chemodosimetric probe for the specific detection of Hg2+ in physiological condition and its utilisation for cell imaging studies

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Abstract

A dithiane derivative of BODIPY is synthesized. This new reagent could be used for the specific and instantaneous detection of Hg2+ in physiological condition. This dithiane reagent reacts specifically with Hg2+ to regenerate the parent BODIPY-aldehyde with consequential change in visually detectable optical responses and this provides the possibility of using this reagent as a colorimetric probe or as a fluorescent biomarker/imaging reagent. Further, non-covalent interactions could be utilized for formation of an inclusion complex with biologically benign β-cyclodextrin for enhancing its solubility in aqueous environment and this included adduct could be used as a fluorescent marker and imaging reagent for Hg2+. Uptake of Hg2+ ions in live HeLa cells, exposed to a solution having Hg2+ ion concentration as low as 2 ppb, could also be detected by confocal laser microscopic studies.

Graphical abstract: New chemodosimetric probe for the specific detection of Hg2+ in physiological condition and its utilisation for cell imaging studies

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Publication details

The article was received on 29 Jun 2013, accepted on 22 Jul 2013 and first published on 23 Jul 2013


Article type: Paper
DOI: 10.1039/C3DT51744F
Citation: Dalton Trans., 2013,42, 15097-15105
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    New chemodosimetric probe for the specific detection of Hg2+ in physiological condition and its utilisation for cell imaging studies

    S. Saha, H. Agarwalla, H. Gupta, M. Baidya, E. Suresh, S. K. Ghosh and A. Das, Dalton Trans., 2013, 42, 15097
    DOI: 10.1039/C3DT51744F

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