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Issue 37, 2013
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Synthesis of iridium and rhodium complexes with new chiral phosphine-NHC ligands based on 1,1′-binaphthyl framework and their application in asymmetric hydrogenation

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Abstract

The first series of chiral phosphine-imidazole carbene ligands based on a 1,1′-binaphthyl framework were synthesized from (R)-2-amine-2′-(diphenylphosphino)-1,1′-binaphthyl (1) in a four-step pathway. After deprotonation of these phosphine-imidazolium salts with LiOtBu, and subsequent complexation with [Ir(COD)Cl]2 and anion exchange with NaBArF, phosphine-carbene chelated iridium complexes (R)-6a and (R)-6b were obtained. Their structures have been characterized by NMR and X-ray diffraction analysis. The NHC-phosphine rhodium complex (R)-6c has been also obtained by a similar synthetic method. These iridium complexes have been applied to catalyze the asymmetric hydrogenation of alkenes to give the corresponding products in moderate to excellent conversion (up to 99%) and moderate enantioselectivities under mild conditions (up to 61% ee).

Graphical abstract: Synthesis of iridium and rhodium complexes with new chiral phosphine-NHC ligands based on 1,1′-binaphthyl framework and their application in asymmetric hydrogenation

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Publication details

The article was received on 02 May 2013, accepted on 04 Jul 2013 and first published on 05 Jul 2013


Article type: Paper
DOI: 10.1039/C3DT51141C
Citation: Dalton Trans., 2013,42, 13599-13606
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    Synthesis of iridium and rhodium complexes with new chiral phosphine-NHC ligands based on 1,1′-binaphthyl framework and their application in asymmetric hydrogenation

    P. Gu, J. Zhang, Q. Xu and M. Shi, Dalton Trans., 2013, 42, 13599
    DOI: 10.1039/C3DT51141C

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