Jump to main content
Jump to site search

Issue 34, 2013
Previous Article Next Article

Bifunctional polypyridyl-Ru(II) complex grafted onto gadolinium-based nanoparticles for MR-imaging and photodynamic therapy

Author affiliations

Abstract

The synthesis, optical properties and efficiency of new multifunctional nanoparticles as theranostic (fluorescence/MRI/PDT) agents are described. They are based on a polysiloxane network and surrounded by gadolinium(III) chelates and ruthenium(II) complexes. The size of the nanoparticles is maintained under 5 nm in order to permit their efficient elimination from the body. Their potential use as a theranostic agent (PDT/MRI) is described. The magnetic properties of the nanoparticles are studied by relaxometry (r1 = 9.21 mM−1 s−1 at 40 MHz; r2/r1 = 1.14) and the signal enhancement is validated by the acquisition of phantoms on a 3 T MRI imager. The therapeutic potential for photodynamic therapy of the nanoparticles has been studied in vitro on HEK293 cells and an effective quantum yield of 0.33 for 1O2 production has been determined in deuterated water.

Graphical abstract: Bifunctional polypyridyl-Ru(ii) complex grafted onto gadolinium-based nanoparticles for MR-imaging and photodynamic therapy

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 10 Apr 2013, accepted on 19 Jun 2013 and first published on 20 Jun 2013


Article type: Paper
DOI: 10.1039/C3DT50946J
Citation: Dalton Trans., 2013,42, 12410-12420
  •   Request permissions

    Bifunctional polypyridyl-Ru(II) complex grafted onto gadolinium-based nanoparticles for MR-imaging and photodynamic therapy

    C. Truillet, F. Lux, J. Moreau, M. Four, L. Sancey, S. Chevreux, G. Boeuf, P. Perriat, C. Frochot, R. Antoine, P. Dugourd, C. Portefaix, C. Hoeffel, M. Barberi-Heyob, C. Terryn, L. van Gulick, G. Lemercier and O. Tillement, Dalton Trans., 2013, 42, 12410
    DOI: 10.1039/C3DT50946J

Search articles by author