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Issue 27, 2013
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Decomposition kinetics of peroxynitrite: influence of pH and buffer

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Abstract

The decay of ONOOH near neutral pH has been examined as a function of isomerization to H+ and NO3, and decomposition to NO2 and O2via O2NOO. We find that in phosphate buffer kisomerization = 1.11 ± 0.01 s−1 and kdisproportionation = (1.3 ± 0.1) × 103 M−1 s−1 at 25 °C and I = 0.2 M. In the presence of 0.1 M tris(hydroxymethyl)aminomethane (Tris), the decay proceeds more rapidly: kdisproportionation = 9 × 103 M−1 s−1. The measured first half-life of the absorbance of peroxynitrite correlates with [Tris]0·([ONOO]0 + [ONOOH]0)2, where the subscript 0 indicates initial concentrations; if this function exceeds 6.3 × 10−12 M3, then Tris significantly accelerates the decomposition of peroxynitrite.

Graphical abstract: Decomposition kinetics of peroxynitrite: influence of pH and buffer

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Publication details

The article was received on 09 Apr 2013, accepted on 03 May 2013 and first published on 23 May 2013


Article type: Paper
DOI: 10.1039/C3DT50945A
Citation: Dalton Trans., 2013,42, 9898-9905
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    Decomposition kinetics of peroxynitrite: influence of pH and buffer

    C. Molina, R. Kissner and W. H. Koppenol, Dalton Trans., 2013, 42, 9898
    DOI: 10.1039/C3DT50945A

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