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Issue 31, 2013
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Synthesis and antiproliferative activity of the heterobimetallic complexes [RuClCp(PPh3)-μ-dmoPTA-1κP:2κ2N,N′-MCl2] (M = Co, Ni, Zn; dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane)

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Abstract

The synthesis and characterization of three novel heterobimetallic derivatives of general formula [RuClCp(PPh3)-μ-dmoPTA-1κP:2κ2N,N′-MCl2] (M = Co (1), Ni (2) and Zn (3), dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane) are described. The sizes of their diffusing units are in agreement with the solid-state structures of 2 and 3, supporting a similar solid-state structure for complex 1. The diamagnetic ruthenium–zinc derivative 3 was fully characterized in solution at 193 K by NMR. Electrochemical properties of the complexes were investigated by cyclic voltammetry, supporting the influence of the {MCl2} moiety on the electronic properties of the Ru-unit. For the three complexes the GI50 values were in the range 0.8–6.5 μM and comparable to those of the standard anticancer drug cis-platin in the same cell lines.

Graphical abstract: Synthesis and antiproliferative activity of the heterobimetallic complexes [RuClCp(PPh3)-μ-dmoPTA-1κP:2κ2N,N′-MCl2] (M = Co, Ni, Zn; dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane)

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Publication details

The article was received on 27 Mar 2013, accepted on 23 May 2013 and first published on 28 Jun 2013


Article type: Paper
DOI: 10.1039/C3DT50829C
Citation: Dalton Trans., 2013,42, 11212-11219
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    Synthesis and antiproliferative activity of the heterobimetallic complexes [RuClCp(PPh3)-μ-dmoPTA-1κP:2κ2N,N′-MCl2] (M = Co, Ni, Zn; dmoPTA = 3,7-dimethyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane)

    M. Serrano-Ruiz, L. M. Aguilera-Sáez, P. Lorenzo-Luis, J. M. Padrón and A. Romerosa, Dalton Trans., 2013, 42, 11212
    DOI: 10.1039/C3DT50829C

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