The Cu(II) complexes of cyclen and two of its heterosubstituted analogues were shown to be efficient oxidative DNA cleavers. The reactivity strongly depends on the heteroatom inserted into the macrocycle (O > S > N).
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Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(II) complexes of heterosubstituted cyclens
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a
Institut für Chemie und Biochemie, Freie Universität Berlin, Fabeckstr. 34/36, D-14195 Berlin, Germany
E-mail: nora.kulak@fu-berlin.de ;
Fax: +49 30 838 52440 ;
Tel: +49 30 838 54697
E-mail: nora.kulak@fu-berlin.de ;
Fax: +49 30 838 52440 ;
Tel: +49 30 838 54697
b
Universität Stuttgart, Institut für Anorganische Chemie, Pfaffenwaldring 55, 70569 Stuttgart, Germay
Dalton Trans., 2013,42, 4357-4360
DOI: 10.1039/C3DT32857K
Received 28 Nov 2012, Accepted 30 Jan 2013
First published online 15 Feb 2013
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