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Issue 9, 2013
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Photoluminescent DNA binding and cytotoxic activity of a platinum(II) complex bearing a tetradentate β-diketiminate ligand

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Abstract

A platinum(II) complex of a monoanionic, tetradentate β-diketiminate (BDI) ligand with pendant quinoline arms, BDIQQH, is reported. The complex, [Pt(BDIQQ)]Cl, is emissive in DMSO, but non-emissive in aqueous buffer. Upon binding DNA in buffer, however, a 150-fold turn-on in emission intensity occurs. Dynamic light scattering and 1H NMR spectroscopy indicate that [Pt(BDIQQ)]Cl forms non-emissive aggregates in aqueous solution; DNA-binding disperses the aggregates leading to the large emission turn-on response. The cytotoxic activity of the complex, measured in two cancer cell lines, is comparable to or better than that of the established anticancer drug cisplatin.

Graphical abstract: Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand

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Publication details

The article was received on 16 Oct 2012, accepted on 31 Oct 2012 and first published on 06 Nov 2012


Article type: Communication
DOI: 10.1039/C2DT32462H
Citation: Dalton Trans., 2013,42, 3176-3180
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    Photoluminescent DNA binding and cytotoxic activity of a platinum(II) complex bearing a tetradentate β-diketiminate ligand

    J. M. Hope, J. J. Wilson and S. J. Lippard, Dalton Trans., 2013, 42, 3176
    DOI: 10.1039/C2DT32462H

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