Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 17, 2013
Previous Article Next Article

Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics

Author affiliations

Abstract

The complex fac-[Mo(CO)3(histidinate)]Na has been reported to be an effective CO-Releasing Molecule in vivo, eliciting therapeutic effects in several animal models of disease. The CO releasing profile of this complex in different settings both in vitro and in vivo reveals that the compound can readily liberate all of its three CO equivalents under biological conditions. The compound has low toxicity and cytotoxicity and is not hemolytic. CO release is accompanied by a decrease in arterial blood pressure following administration in vivo. We studied its behavior in solution and upon the interaction with proteins. Reactive oxygen species (ROS) generation upon exposure to air and polyoxomolybdate formation in soaks with lysozyme crystals were observed as processes ensuing from the decomposition of the complex and the release of CO.

Graphical abstract: Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 19 Sep 2012, accepted on 16 Nov 2012 and first published on 16 Nov 2012


Article type: Paper
DOI: 10.1039/C2DT32174B
Citation: Dalton Trans., 2013,42, 5985-5998
  •   Request permissions

    Characterization of a versatile organometallic pro-drug (CORM) for experimental CO based therapeutics

    J. D. Seixas, A. Mukhopadhyay, T. Santos-Silva, L. E. Otterbein, D. J. Gallo, S. S. Rodrigues, B. H. Guerreiro, A. M. L. Gonçalves, N. Penacho, A. R. Marques, A. C. Coelho, P. M. Reis, M. J. Romão and C. C. Romão, Dalton Trans., 2013, 42, 5985
    DOI: 10.1039/C2DT32174B

Search articles by author