Jump to main content
Jump to site search

Issue 7, 2013
Previous Article Next Article

Importance of ligand structure in DNA/protein binding, mutagenicity, excision repair and nutritional aspects of chromium(III) complexes

Author affiliations

Abstract

Chromium is extensively used in leather, chrome plating and refining industries. On one hand the occupational exposure to chromium leads to cancer, whereas on the contrary certain Cr(III) compounds have been proposed as nutritional supplements for Type II diabetes and as muscle building agents. Despite the positive outlook of chromium as a bio-essential element, there is increasing concern over the therapeutic application of Cr(III) based supplements, its bioavailability and toxicity profile. In this perspective, we discuss the role of ligand structure in mediating the interaction of chromium(III) complexes with DNA/protein, their mutagenic outcomes, adduct reparability and as nutritional supplements.

Graphical abstract: Importance of ligand structure in DNA/protein binding, mutagenicity, excision repair and nutritional aspects of chromium(iii) complexes

Back to tab navigation

Publication details

The article was received on 14 Sep 2012, accepted on 14 Nov 2012 and first published on 15 Nov 2012


Article type: Perspective
DOI: 10.1039/C2DT32124F
Citation: Dalton Trans., 2013,42, 2337-2346
  •   Request permissions

    Importance of ligand structure in DNA/protein binding, mutagenicity, excision repair and nutritional aspects of chromium(III) complexes

    V. G. Vaidyanathan, Y. Asthana and B. U. Nair, Dalton Trans., 2013, 42, 2337
    DOI: 10.1039/C2DT32124F

Search articles by author

Spotlight

Advertisements