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Issue 7, 2013
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Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death

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Abstract

Two hybrid compounds comprising an antimetastatic ruthenium–arene fragment tethered to an indazole-3-carboxylic acid derivative that inhibits aerobic glycolysis in cancer cells have been prepared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent synergistic action between the two components observed.

Graphical abstract: Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death

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Publication details

The article was received on 24 Aug 2012, accepted on 21 Nov 2012 and first published on 22 Nov 2012


Article type: Communication
DOI: 10.1039/C2DT31936E
Citation: Dalton Trans., 2013,42, 2347-2350
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    Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death

    A. A. Nazarov, D. Gardini, M. Baquié, L. Juillerat-Jeanneret, T. P. Serkova, E. P. Shevtsova, R. Scopelliti and P. J. Dyson, Dalton Trans., 2013, 42, 2347
    DOI: 10.1039/C2DT31936E

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