Issue 7, 2013
From the journal:

Dalton Transactions

Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death†

Alexey A. Nazarov,*ab   Daniel Gardini,a   Mathurin Baquié,a   Lucienne Juillerat-Jeanneret,c   Tatiana P. Serkova,d   Elena P. Shevtsova,d   Rosario Scopellitia  and  Paul J. Dyson*a  

* Corresponding authors

a Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland
E-mail: paul.dyson@epfl.ch
Fax: +41-21-6939780
Tel: +41-21-6939854

b Moscow State University, Department of Chemistry, Leninskie gory, Moscow, Russia
E-mail: alexey.nazarov@me.com

c University Institute of Pathology Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland

d Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia

Abstract

Two hybrid compounds comprising an antimetastatic ruthenium–arene fragment tethered to an indazole-3-carboxylic acid derivative that inhibits aerobic glycolysis in cancer cells have been prepared and evaluated in a variety of cancer cell lines, including highly relevant human glioblastoma cells, with an apparent synergistic action between the two components observed.

Graphical abstract: Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death

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Article information

DOI
https://doi.org/10.1039/C2DT31936E
Article type
Communication
Submitted
24 Aug 2012
Accepted
21 Nov 2012
First published
22 Nov 2012

Dalton Trans., 2013,42, 2347-2350

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Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death

A. A. Nazarov, D. Gardini, M. Baquié, L. Juillerat-Jeanneret, T. P. Serkova, E. P. Shevtsova, R. Scopelliti and P. J. Dyson, Dalton Trans., 2013, 42, 2347 DOI: 10.1039/C2DT31936E

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