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Issue 6, 2013
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Multifunctional magnetic fluorescent hybrid nanoparticles as carriers for the hydrophobic anticancer drug 5-fluorouracil

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Abstract

In this paper fluorescent magnetic Fe3O4@m-SiO2@YPO4:Tb3+ particles with a size of 52 nm have been prepared and characterized. The surface of the nanoparticles was modified with β-cyclodextrin and folic acid using glutathione as a linker. The hydrophobic anticancer drug 5-fluorouracil (5-FU) was successfully loaded on the fluorescent magnetic nanoparticles via formation of the 5-FU–CD inclusion complex. The overall size of the drug conjugate is 71 nm and the particles are highly stable in an aqueous medium without any deterioration of HD size. The drug conjugate favors more release at lower pH owing to instability of the 5-FU–CD inclusion complex. These results demonstrate that the developed multifunctional nanocomposite can be potentially used in magnetically guided delivery of 5-FU.

Graphical abstract: Multifunctional magnetic fluorescent hybrid nanoparticles as carriers for the hydrophobic anticancer drug 5-fluorouracil

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Publication details

The article was received on 08 Aug 2012, accepted on 09 Nov 2012 and first published on 09 Nov 2012


Article type: Paper
DOI: 10.1039/C2DT31812A
Citation: Dalton Trans., 2013,42, 2224-2231
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    Multifunctional magnetic fluorescent hybrid nanoparticles as carriers for the hydrophobic anticancer drug 5-fluorouracil

    S. Sahu and S. Mohapatra, Dalton Trans., 2013, 42, 2224
    DOI: 10.1039/C2DT31812A

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