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Issue 6, 2013
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Cyclic decapeptide gramicidin S derivatives containing phosphines: novel ligands for asymmetric catalysis

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Abstract

The cyclic peptide gramicidin S was used as a rigid template to provide novel peptide-based bisphosphine ligands for transition metal catalysis. Two bisphosphine-coordinated Rh(I) complexes allowed asymmetric hydrogenation with 10–52% ee and the corresponding Pd(II) analogues catalysed asymmetric allylic alkylation with 13–15% ee.

Graphical abstract: Cyclic decapeptide gramicidin S derivatives containing phosphines: novel ligands for asymmetric catalysis

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Publication details

The article was received on 03 Aug 2012, accepted on 27 Nov 2012 and first published on 28 Nov 2012


Article type: Communication
DOI: 10.1039/C2DT31782F
Citation: Dalton Trans., 2013,42, 1973-1978
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    Cyclic decapeptide gramicidin S derivatives containing phosphines: novel ligands for asymmetric catalysis

    G. Guisado-Barrios, B. K. Muñoz, P. C. J. Kamer, B. Lastdrager, G. van der Marel, M. Overhand, M. Vega-Vázquez and M. Martin-Pastor, Dalton Trans., 2013, 42, 1973
    DOI: 10.1039/C2DT31782F

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