Jump to main content
Jump to site search

Issue 1, 2013
Previous Article Next Article

Catalytic chemical transformations with conformationally dynamic catalytic systems

Author affiliations

Abstract

Proteins, RNA, and other functional biomacromolecules are sophisticated chemical entities that have evolved over billions of years. Their catalytic, constitutional, and communicating functions are intimately related to their three-dimensional molecular architecture and are exquisitely regulated in a spatiotemporal manner by conformational changes through allosteric regulators and a myriad of reversible and unidirectional posttranslational modifications. Their organized functional diversity is the key to the orderly and timely progression of complicated biological events. The main focus in the development of artificial catalysts is to accelerate a specific chemical transformation of interest, and extensive efforts have been devoted to fine-tuning catalytic activity. Here, we review recent developments of multistate catalysts able to perform distinct catalytic functions, with emphasis on the tight link between the structural modification of the conformationally flexible catalysts and the functional change. Although this field is still in its infancy with a simple output, continued advances will allow us to create intriguing systems with organized multitask output in an intricate molecular ensemble.

Graphical abstract: Catalytic chemical transformations with conformationally dynamic catalytic systems

Back to tab navigation

Publication details

The article was received on 23 Apr 2012, accepted on 31 Jul 2012 and first published on 04 Sep 2012


Article type: Minireview
DOI: 10.1039/C2CY20257C
Citation: Catal. Sci. Technol., 2013,3, 41-57
  •   Request permissions

    Catalytic chemical transformations with conformationally dynamic catalytic systems

    N. Kumagai and M. Shibasaki, Catal. Sci. Technol., 2013, 3, 41
    DOI: 10.1039/C2CY20257C

Search articles by author

Spotlight

Advertisements