Issue 13, 2013

Electrical biosensors and the label free detection of protein disease biomarkers

Abstract

Electrical detection methodologies are likely to underpin the progressive drive towards miniaturised, sensitive and portable biomarker detection protocols. In being easily integrated within standard electronic microfabrication formats, and developing capability in microfluidics, the facile multiplexed detection of a range of proteins in a small analytical volume becomes entirely feasible with something costing just a few thousand pounds and benchtop or handheld in scale. In this review, we focus on recent important advances in label free assays of protein using a number of electrical methods, including those based on electrochemical impedance spectroscopy (EIS), amperometry/voltammetry, potentiometry, conductometry and field-effect methods. We introduce their mechanistic features and examples of application and sensitivity. The current state of the art, real world applications and challenges are outlined.

Graphical abstract: Electrical biosensors and the label free detection of protein disease biomarkers

Article information

Article type
Review Article
Submitted
26 Feb 2013
First published
24 Apr 2013

Chem. Soc. Rev., 2013,42, 5944-5962

Electrical biosensors and the label free detection of protein disease biomarkers

X. Luo and J. J. Davis, Chem. Soc. Rev., 2013, 42, 5944 DOI: 10.1039/C3CS60077G

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