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Issue 14, 2013
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Thiol-addition reactions and their applications in thiol recognition

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Abstract

Because of the biological importance of thiols, the development of probes for thiols has been an active research area in recent years. In this review, we summarize the results of recent exciting reports regarding thiol-addition reactions and their applications in thiol recognition. The examples reported can be classified into four reaction types including 1,1, 1,2, 1,3, 1,4 addition reactions, according to their addition mechanisms, based on different Michael acceptors. In all cases, the reactions are coupled to color and/or emission changes, although some examples dealing with electrochemical recognition have also been included. The use of thiol-addition reactions is a very simple and straightforward procedure for the preparation of thiol-sensing probes.

Graphical abstract: Thiol-addition reactions and their applications in thiol recognition

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Publication details

The article was received on 07 Feb 2013 and first published on 23 May 2013


Article type: Review Article
DOI: 10.1039/C3CS60055F
Citation: Chem. Soc. Rev., 2013,42, 6032-6059
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    Thiol-addition reactions and their applications in thiol recognition

    C. Yin, F. Huo, J. Zhang, R. Martínez-Máñez, Y. Yang, H. Lv and S. Li, Chem. Soc. Rev., 2013, 42, 6032
    DOI: 10.1039/C3CS60055F

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