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Issue 13, 2013
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Manipulating biological agents and cells in micro-scale volumes for applications in medicine

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Abstract

Recent technological advances provide new tools to manipulate cells and biological agents in micro/nano-liter volumes. With precise control over small volumes, the cell microenvironment and other biological agents can be bioengineered; interactions between cells and external stimuli can be monitored; and the fundamental mechanisms such as cancer metastasis and stem cell differentiation can be elucidated. Technological advances based on the principles of electrical, magnetic, chemical, optical, acoustic, and mechanical forces lead to novel applications in point-of-care diagnostics, regenerative medicine, in vitro drug testing, cryopreservation, and cell isolation/purification. In this review, we first focus on the underlying mechanisms of emerging examples for cell manipulation in small volumes targeting applications such as tissue engineering. Then, we illustrate how these mechanisms impact the aforementioned biomedical applications, discuss the associated challenges, and provide perspectives for further development.

Graphical abstract: Manipulating biological agents and cells in micro-scale volumes for applications in medicine

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Publication details

The article was received on 03 Feb 2013 and first published on 11 Apr 2013


Article type: Review Article
DOI: 10.1039/C3CS60042D
Citation: Chem. Soc. Rev., 2013,42, 5788-5808
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    Manipulating biological agents and cells in micro-scale volumes for applications in medicine

    S. Tasoglu, U. A. Gurkan, S. Wang and U. Demirci, Chem. Soc. Rev., 2013, 42, 5788
    DOI: 10.1039/C3CS60042D

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