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Issue 14, 2013
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Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

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Abstract

Mass spectrometry (MS) has emerged as an important tool for studying anticancer metallodrugs in complex biological samples and for characterising their interactions with biomolecules and potential targets on a molecular level. The exact modes-of-action of these coordination compounds and especially of next generation drug candidates have not been fully elucidated. Due to the fact that DNA is considered a crucial target for platinum chemotherapeutics, metallodrug–DNA binding studies dominated the field for a long time. However, more recently, alternative targets were considered, including enzymes and proteins that may play a role in the overall pharmacological and toxicological profile of metallodrugs. This review focuses on MS-based techniques for studying anticancer metallodrugs in vivo, in vitro and in situ to delineate their modes-of-action.

Graphical abstract: Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

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Publication details

The article was received on 31 Dec 2012 and first published on 09 May 2013


Article type: Review Article
DOI: 10.1039/C3CS35532B
Citation: Chem. Soc. Rev., 2013,42, 6186-6199
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    Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

    C. G. Hartinger, M. Groessl, S. M. Meier, A. Casini and P. J. Dyson, Chem. Soc. Rev., 2013, 42, 6186
    DOI: 10.1039/C3CS35532B

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