Jump to main content
Jump to site search

Issue 16, 2013
Previous Article Next Article

Recent advances in dynamic covalent chemistry

Author affiliations

Abstract

Dynamic covalent chemistry (DCvC) has been strongly integrated into diverse research fields, and has enabled easy access to a variety of combinatorial libraries, 2-D macrocycles, and 3-D molecular cages that target many important applications, such as drug discovery, biotechnology, molecular separation, light harvesting, etc. DCvC relies on the reversible formation and breaking of rather strong covalent bonding within molecules. Therefore it combines the error-correction capability of supramolecular chemistry and the robustness of covalent bonding. Compared to those supramolecular interactions, dynamic covalent reactions usually have slower kinetics and require the assistance of catalysts to achieve rapid equilibrium. Although the scope of dynamic covalent reactions is rapidly expanding, the reversible reactions suitable for DCvC are still very limited. The identification and development of new dynamic reactions and catalysts would be critical for the further advancement of DCvC. This review covers the recent development of dynamic covalent reactions as well as their applications.

Graphical abstract: Recent advances in dynamic covalent chemistry

Back to tab navigation

Publication details

The article was received on 03 Feb 2013 and first published on 10 Jun 2013


Article type: Tutorial Review
DOI: 10.1039/C3CS60044K
Citation: Chem. Soc. Rev., 2013,42, 6634-6654
  •   Request permissions

    Recent advances in dynamic covalent chemistry

    Y. Jin, C. Yu, R. J. Denman and W. Zhang, Chem. Soc. Rev., 2013, 42, 6634
    DOI: 10.1039/C3CS60044K

Search articles by author

Spotlight

Advertisements