without changing your settings we'll assume you are happy to receive all RSC cookies.
You can change your cookie settings by navigating to our Privacy and Cookies page and following the instructions. These instructions
are also obtainable from the privacy link at the bottom of any RSC page.
Departamento de Química Orgánica (Módulo 1), Facultad de Ciencias, Universidad Autónoma de Madrid, Francisco Tomás y Valiente 7, 28049-Madrid, Spain
; Fax: +34 91497 3966
; Tel: +34 91497 3875
Departamento de Química Inorgánica (Módulo-7), Facultad de Ciencias, Universidad Autónoma de Madrid, Francisco Tomás y Valiente 7, 28049-Madrid, Spain
; Fax: +34 91497 4833
; Tel: +34 91497 2539
Chem. Soc. Rev., 2013,42, 774-793
11 Sep 2012,
First published online
15 Nov 2012
In the last decade, organocatalysis, the use of small chiral organic molecules as catalysts, has proven to be a valuable and attractive tool for the synthesis of enantiomerically enriched molecules. A number of organocatalysts and processes, such as one-pot, tandem, cascade or multicomponent reactions, have been reported to date. Furthermore, the many advantages of organocatalysis – robust, non-toxic, affordable, inert atmosphere, easy reaction manipulation, etc. – allow the preparation of bioactive compounds using simple and metal-free procedures, thus avoiding false positives in the biological evaluation. This mini-review focuses on medicinal chemistry programs that have synthesized biologically active compounds using one or more organocatalytic steps. In this respect, the potential of organocatalytic methods for enabling the chemical synthesis of important medicinal targets will be highlighted.
Fetching data from CrossRef. This may take some time to load.