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Issue 38, 2013
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Towards design principles for determining the mechanical stability of proteins

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Abstract

The successful integration of proteins into bionanomaterials with specific and desired functions requires an accurate understanding of their material properties. Two such important properties are their mechanical stability and malleability. While single molecule manipulation techniques now routinely provide access to these, there is a need to move towards predictive tools that can rationally identify proteins with desired material properties. We provide a comprehensive review of the available experimental data on the single molecule characterisation of proteins using the atomic force microscope. We uncover a number of empirical relationships between the measured mechanical stability of a protein and its malleability, which provide a set of simple tools that might be employed to estimate properties of previously uncharacterised proteins.

Graphical abstract: Towards design principles for determining the mechanical stability of proteins

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Publication details

The article was received on 21 May 2013, accepted on 13 Aug 2013 and first published on 15 Aug 2013


Article type: Perspective
DOI: 10.1039/C3CP52142G
Citation: Phys. Chem. Chem. Phys., 2013,15, 15767-15780
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    Towards design principles for determining the mechanical stability of proteins

    T. Hoffmann, K. M. Tych, M. L. Hughes, D. J. Brockwell and L. Dougan, Phys. Chem. Chem. Phys., 2013, 15, 15767
    DOI: 10.1039/C3CP52142G

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