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Issue 28, 2013
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Chitosan conjugates for DNA delivery

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Abstract

Graft copolymers of chitosan and maltodextrin were synthesized by reductive amination of a low molecular weight chitosan. The degree of substitution is 70% or above, as quantified by nuclear magnetic resonance spectroscopy, at molar ratios of chitosan glucosamine units and maltodextrin of 1 : 1 and 1 : 5. The high substitution degree generates a water-soluble compound at pH 7.4 by reducing the amino groups of chitosan. In addition, the copolymer self-assembles into spherical nanoparticles with diameters of about 300 nm. The mass polymer/DNA ratios at the isoelectric point are within the range of 3–3.5 for chitosanmaltodextrin nanoparticles as determined by electrophoretic mobility measurements. These results confirm that DNA interacts efficiently with the copolymer nanoparticles indicating a potential application of the system for DNA delivery.

Graphical abstract: Chitosan conjugates for DNA delivery

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Publication details

The article was received on 20 Mar 2013, accepted on 16 May 2013 and first published on 13 Jun 2013


Article type: Paper
DOI: 10.1039/C3CP51215K
Citation: Phys. Chem. Chem. Phys., 2013,15, 11893-11899
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    Chitosan conjugates for DNA delivery

    D. Paiva, G. Ivanova, M. do Carmo Pereira and S. Rocha, Phys. Chem. Chem. Phys., 2013, 15, 11893
    DOI: 10.1039/C3CP51215K

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