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Issue 24, 2013
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Mechanism of one-electron oxidation of metformin in aqueous solution

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Abstract

Hydroxyl free radical-induced oxidation of metformin was studied in aqueous solution as a function of the pH. Hydroxyl free radicals were generated by gamma radiolysis of water and the oxidation end-products were quantified by high-performance liquid chromatography coupled to mass spectrometry (HPLC/MS), as a function of the radiation dose. This work is a joint experimental and theoretical (DFT) approach that has paved the way towards a comprehensive rationalization of the one-electron mechanisms of MTF oxidation, as a function of the pH.

Graphical abstract: Mechanism of one-electron oxidation of metformin in aqueous solution

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Publication details

The article was received on 08 Feb 2013, accepted on 19 Apr 2013 and first published on 22 Apr 2013


Article type: Paper
DOI: 10.1039/C3CP50602A
Citation: Phys. Chem. Chem. Phys., 2013,15, 9871-9878
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    Mechanism of one-electron oxidation of metformin in aqueous solution

    P. Trouillas, C. Marchetti, D. Bonnefont-Rousselot, R. Lazzaroni, D. Jore, M. Gardès-Albert and F. Collin, Phys. Chem. Chem. Phys., 2013, 15, 9871
    DOI: 10.1039/C3CP50602A

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