Issue 24, 2013
From the journal:

Physical Chemistry Chemical Physics

Mechanism of one-electron oxidation of metformin in aqueous solution†

P. Trouillas,*abc   C. Marchetti,d   D. Bonnefont-Rousselot,ef   R. Lazzaroni,b   D. Jore,d   M. Gardès-Albertd  and  F. Collin*dgh  

* Corresponding authors

a INSERM UMR-S850, Faculté de Pharmacie, Université de Limoges, 2 rue du Docteur Marcland, 87025 Limoges Cedex, France
E-mail: patrick.trouillas@unilim.fr

b Laboratoire de Chimie des Matériaux Nouveaux, Université de Mons Place du Parc 20, B-7000 Mons, Belgium

c Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacký University Olomouc, tr. 17 listopadu, 771 46 Olomouc, Czech Republic

d UFR Biomédicale des Saints-Pères, Université Paris Descartes, 45 rue des Saints Pères, 75006 Paris, France

e EA 4466, Département de Biologie Expérimentale, Métabolique et Clinique, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, 4 avenue de l'Observatoire, 75006 Paris, France

f Service de Biochimie Métabolique, Hôpitaux Universitaires Pitié-Salpêtrière – Charles Foix (AP-HP), 47-83 boulevard de l'Hôpital, 75013 Paris, France

g Université de Toulouse, UPS, UMR 152 Pharma-Dev, Université Toulouse 3, F-31062 Toulouse cedex 09, France

h Institut de Recherche pour le Développement (IRD), UMR 152 Pharma-Dev, F-31062 Toulouse cedex 09, France
E-mail: fabrice.collin@univ-tlse3.fr

Abstract

Hydroxyl free radical-induced oxidation of metformin was studied in aqueous solution as a function of the pH. Hydroxyl free radicals were generated by gamma radiolysis of water and the oxidation end-products were quantified by high-performance liquid chromatography coupled to mass spectrometry (HPLC/MS), as a function of the radiation dose. This work is a joint experimental and theoretical (DFT) approach that has paved the way towards a comprehensive rationalization of the one-electron mechanisms of MTF oxidation, as a function of the pH.

Graphical abstract: Mechanism of one-electron oxidation of metformin in aqueous solution

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Article information

DOI
https://doi.org/10.1039/C3CP50602A
Article type
Paper
Submitted
08 Feb 2013
Accepted
19 Apr 2013
First published
22 Apr 2013

Phys. Chem. Chem. Phys., 2013,15, 9871-9878

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Mechanism of one-electron oxidation of metformin in aqueous solution

P. Trouillas, C. Marchetti, D. Bonnefont-Rousselot, R. Lazzaroni, D. Jore, M. Gardès-Albert and F. Collin, Phys. Chem. Chem. Phys., 2013, 15, 9871 DOI: 10.1039/C3CP50602A

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